AJP - Gastrointestinal and Liver Physiology, Vol 245, Issue 1 78-G84, Copyright © 1983 by American Physiological Society
Regionally perfused fatty acids augment acid-induced canine pancreatic secretion
A. S. Fink, M. Luxenburg and J. H. Meyer
To study interactions between hydrochloric acid and fatty acids on
pancreatic secretion, six dogs with chronic gastric, pancreatic, and small
intestinal cannulas received various combinations of the following
intestinal perfusates: 20, 40, and 80 mM hydrochloric acid, oleate,
dodecanoate, or 0.15 M saline. Regional intestinal perfusion (a proximal
segment measuring 45 cm from the pancreatic duct versus the remaining small
bowel) was utilized to separate the aqueous acid and lipid solutions. Both
oleate and dodecanoate augmented the bicarbonate output induced by
intraluminal acidification. In other experiments, intraluminal oleate, when
combined with exogeneous intravenous secretin (12.5-900 ng . kg-1 . h-1),
potentiated the secretin-induced bicarbonate output at low secretin doses.
Dodecanoate also increased secretin-induced bicarbonate output. In all of
these studies, protein outputs were increased by intestinal fatty acids. It
is concluded that intestinal fatty acids can enhanced acid-induced canine
pancreatic secretion.
