AJP - GI Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol 245: G99-G105, 1983;
0193-1857/83 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Solomon, T. E.
Right arrow Articles by Morisset, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Solomon, T. E.
Right arrow Articles by Morisset, J.

AJP - Gastrointestinal and Liver Physiology, Vol 245, Issue 1 99-105, Copyright © 1983 by American Physiological Society

ARTICLES

Cell site and time course of DNA synthesis in pancreas after caerulein and secretin

T. E. Solomon, M. Vanier and J. Morisset

Pancreatic weight, [3H]-thymidine incorporation into DNA, labeling indices, and total DNA and RNA content were measured in rats treated with vehicle or 1 microgram/kg caerulein, 100 micrograms/kg secretin, or a combination of these peptides injected every 8 h for 1-5 days. Incorporation of [3H]thymidine into DNA increased 12-fold after 2 days of treatment with the combination of peptides. DNA content increased after 3 days and reached a level 1.8 times control after 5 days. Autoradiography showed that two cell types, acinar and an unidentified type, were the sites of increased DNA synthesis. Different patterns of labeling were seen in the two populations: acinar cell labeling indices were increased at 1 and 2 days (20-fold) and then fell; nonacinar cells showed an increase only after 2 days and maintained this increase after 5 days. Potentiation (greater than additive effects) was found when caerulein and secretin were injected together for all measurements except RNA content. These data indicate that DNA synthesis in two cell populations is affected by secretin and caerulein and support the occurrence of potentiation between secretin and caerulein for trophic effects on the exocrine pancreas.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
L. Guo, M. D. Sans, G. T. Gurda, S.-H. Lee, S. A. Ernst, and J. A. Williams
Induction of early response genes in trypsin inhibitor-induced pancreatic growth
Am J Physiol Gastrointest Liver Physiol, February 1, 2007; 292(2): G667 - G677.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
K. A. Lacourse, L. J. Swanberg, P. J. Gillespie, J. F. Rehfeld, T. L. Saunders, and L. C. Samuelson
Pancreatic function in CCK-deficient mice: adaptation to dietary protein does not require CCK
Am J Physiol Gastrointest Liver Physiol, May 1, 1999; 276(5): G1302 - G1309.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. Schafer, S. E. Ross, M. J. Bragado, G. E. Groblewski, S. A. Ernst, and J. A. Williams
A Role for the p38 Mitogen-activated Protein Kinase/Hsp 27 Pathway in Cholecystokinin-induced Changes in the Actin Cytoskeleton in Rat Pancreatic Acini
J. Biol. Chem., September 11, 1998; 273(37): 24173 - 24180.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Dabrowski, JoyceA. VanderKuur, C. Carter-Su, and JohnA. Williams
Cholecystokinin Stimulates Formation of Shc-Grb2 Complex in Rat Pancreatic Acinar Cells through a Protein Kinase C-dependent Mechanism
J. Biol. Chem., October 25, 1996; 271(43): 27125 - 27129.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online