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Am J Physiol Gastrointest Liver Physiol 245: G321-G324, 1983;
0193-1857/83 $5.00
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AJP - Gastrointestinal and Liver Physiology, Vol 245, Issue 2 321-G324, Copyright © 1983 by American Physiological Society

ARTICLES

Vasopressin modulates liver regeneration in the Brattleboro rat

W. E. Russell and N. L. Bucher

Liver regeneration following partial hepatectomy is significantly impaired in rats with hereditary vasopressin deficiency (Brattleboro strain), both in rate of DNA synthesis and in return of liver DNA content to normal. Vasopressin treatment at physiological doses ameliorates the defect and thus appears to be an important modulator of liver regeneration in response to partial hepatectomy in the rat.


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