AJP - Gastrointestinal and Liver Physiology, Vol 246, Issue 3 274-G280, Copyright © 1984 by American Physiological Society
Intravenous mixed amino acids and fats do not stimulate exocrine pancreatic secretion
B. E. Stabile, M. Borzatta, R. S. Stubbs and H. T. Debas
We compared the responses of the canine exocrine pancreas to intraduodenal
versus intravenous administration of mixed amino acids, fat emulsion, and
glucose. Graded doses of amino acid mixture and of fat emulsion gave graded
responses in volume, protein, and bicarbonate when administered
intraduodenally. In contrast, the same doses of the amino acid mixture and
fat emulsion administered by central intravenous infusion caused no
significant pancreatic secretion of volume, protein, or bicarbonate. Graded
doses of glucose caused no statistically significant pancreatic secretion
whether they were given intraduodenally or intravenously. We conclude,
contrary to a previously published observation, that amino acids and fats
given parenterally do not stimulate pancreatic secretion. As a corollary,
it is reasonable to assume that the pancreas is not stimulated during total
parenteral nutrition with acute pancreatitis or a pancreatic fistula.
