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Am J Physiol Gastrointest Liver Physiol 246: G325-G330, 1984;
0193-1857/84 $5.00
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AJP - Gastrointestinal and Liver Physiology, Vol 246, Issue 4 325-G330, Copyright © 1984 by American Physiological Society

ARTICLES

Invariant relation between total acid secretion and secretagogue exposure: secretory dynamics in bullfrog

E. B. Ekblad and V. Licko

Using a continuous recording of acid secretion in frog gastric mucosa by pH-stat interfaced with a microcomputer, the pattern of secretion rate was studied under variable concentrations and durations of stimulation by histamine and forskolin. This tissue can respond with only a limited range of secretory rates. Larger concentrations and/or longer durations of stimulation may result in a secretion rate pattern prolonged far beyond the duration of stimulation. Although for the concentration-response curve the steady-state or peak acid secretion varies with the duration of stimulation, total acid secreted as a function of exposure to stimulator (time integral of the stimulatory pattern) is independent of the stimulatory pattern.




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