AJP - Gastrointestinal and Liver Physiology, Vol 246, Issue 5 535-G542, Copyright © 1984 by American Physiological Society

ARTICLES

Plasma secretin and pancreatic response to various stimulants including a meal

K. Gyr, C. Beglinger, M. Fried, U. Grotzinger, L. Kayasseh, G. A. Stalder and J. Girard

In dogs with gastric and duodenal Thomas cannulas, we investigated the threshold dose range of exogenous secretin and intraduodenal HCl for pancreatic bicarbonate secretion and, with a recently developed radioimmunoassay, measured the increase in plasma secretin concentrations. Synthetic secretin (2.5, 7.5, and 22.5 ng X kg-1 X h-1) was dissolved in saline or 0.1% dog albumin and given with or without a background infusion of 30 ng X kg-1 X h-1 of caerulein. The minimal dose of secretin that elicited a significant pancreatic bicarbonate response as well as an increase in plasma secretin concentration was 7.5 ng X kg-1 X h-1 when administered with albumin and 22.5 ng X kg-1 X h-1 without albumin. The threshold dose for duodenal HCl was 2 mmol X h-1. The threshold secretin dose for bicarbonate secretion and for an increase in plasma secretin levels was unchanged with a background caerulein infusion. Furthermore, postprandial secretin concentrations were measured. After a meat meal plasma secretin release appeared to occur in spikes up to 10 pmol X l-1 corresponding to secretin levels seen during infusion of 7.5 ng X kg-1 X h-1 of secretin and intraduodenal acid perfusion at a dose of 2 mmol X h-1.

This article has been cited by other articles:

				T. E. Solomon, J. H. Walsh, L. Bussjaeger, Y. Zong, J. W. Hamilton, F. J. Ho, T. D. Lee, and J. R. Reeve Jr. COOH-terminally extended secretins are potent stimulants of pancreatic secretion Am J Physiol Gastrointest Liver Physiol, April 1, 1999; 276(4): G808 - G816. [Abstract] [Full Text] [PDF]