AJP - GI Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol 247: G419-G426, 1984;
0193-1857/84 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Young, G. P.
Right arrow Articles by Alpers, D. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Young, G. P.
Right arrow Articles by Alpers, D. H.

AJP - Gastrointestinal and Liver Physiology, Vol 247, Issue 4 419-G426, Copyright © 1984 by American Physiological Society

ARTICLES

Hepatic clearance of rat plasma intestinal alkaline phosphatase

G. P. Young, I. S. Rose, S. Cropper, S. Seetharam and D. H. Alpers

The mechanism and route of clearance of intestinal alkaline phosphatase from plasma have been studied in rats to define the magnitude of hepatic extraction and biliary excretion of the enzyme. Plasma clearance, tissue distribution, and biliary excretion of enzyme were followed after intravenous administration of physiological amounts of 125I-labeled rat intestinal alkaline phosphatase. The plasma disappearance curve was biphasic; the initial phase was rapid, during which 50% of injected enzyme was selectively extracted by the liver over 5 min. Less than 4% of total hepatic radioactivity was excreted into bile over 80 min; this was shown by chromatographic analysis to be degraded enzyme only. Rapid clearance of enzyme could be significantly slowed by injection of large amounts of mannan or N-acetylglucosamine-bovine serum albumin, but not by desialylated fetuin, demonstrating that clearance was probably mediated by mannose/N-acetylglucosamine-specific receptors. It is concluded that, under physiological conditions, rat plasma intestinal alkaline phosphatase is rapidly cleared from the circulation by the liver. However, biliary excretion of undergraded enzyme is negligible, and a physiologically significant enterohepatic circulation seems most unlikely.


This article has been cited by other articles:


Home page
 CarcinogenesisHome page
K. L. Rickard, P. R. Gibson, G. P. Young, and W. A. Phillips
Activation of protein kinase C augments butyrate-induced differentiation and turnover in human colonic epithelial cells in vitro
Carcinogenesis, June 1, 1999; 20(6): 977 - 984.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
J M Mariadason, A Catto-Smith, and P R Gibson
Modulation of distal colonic epithelial barrier function by dietary fibre in normal rats
Gut, March 1, 1999; 44(3): 394 - 399.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
P R Gibson, I Birchall, O Rosella, V Albert, C F Finch, D H Barkla, and G P Young
Urokinase and the intestinal mucosa: evidence for a role in epithelial cell turnover
Gut, November 1, 1998; 43(5): 656 - 663.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
C. P. Tran, M. Familari, L. M. Parker, R. H. Whitehead, and A. S. Giraud
Short-chain fatty acids inhibit intestinal trefoil factor gene expression in colon cancer cells
Am J Physiol Gastrointest Liver Physiol, July 1, 1998; 275(1): G85 - G94.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online