AJP - Gastrointestinal and Liver Physiology, Vol 248, Issue 5 532-G538, Copyright © 1985 by American Physiological Society
Dose-response effects of atropine on pancreatic response to secretin before and after truncal vagotomy
M. V. Singer, W. Niebel, K. H. Uhde, D. Hoffmeister and H. Goebell
In dogs with gastric and pancreatic fistulas, we studied the effect of
intravenous atropine in doses ranging from 0.9 to 58 nmol X kg-1 X h-1 on
the pancreatic secretory response to secretin before and after truncal
vagotomy. Truncal vagotomy did not alter the incremental bicarbonate
response to secretin. Before and after truncal vagotomy, 7 nmol X kg-1 X
h-1 and all higher doses of atropine sulfate significantly decreased the
bicarbonate response to low doses (5.2 and 10.3 pmol X kg-1 X h-1) of
secretin but had no significant effect on responses to high doses (20.5 and
41 pmol X kg-1 X h-1). The inhibitory potency of the effective doses of
atropine did not differ significantly. Secretin did not stimulate
pancreatic protein output above basal. Truncal vagotomy reduced protein
output basally and during secretin by about 50%. Before and after truncal
vagotomy, 7 nmol X kg-1 X h-1 and all higher doses of atropine
significantly decreased protein output basally and during secretin.
Secretin and truncal vagotomy did not alter basal heart rate. Only the
three highest doses (14, 29, and 58 nmol X kg-1 X h-1) of atropine
significantly increased heart rate.(ABSTRACT TRUNCATED AT 250 WORDS)
