AJP - Gastrointestinal and Liver Physiology, Vol 249, Issue 2 294-G298, Copyright © 1985 by American Physiological Society
Effect of proglumide on rat pancreatic growth
T. Yamaguchi, K. Tabata and L. R. Johnson
Proglumide, a glutaramic acid derivative, is a specific competitive
inhibitor of gastrin and cholecystokinin (CCK) receptors. As such, it
blocks gastrin-stimulated acid secretion, the trophic effect of gastrin,
and CCK-stimulated smooth muscle contraction and acinar cell secretion. In
the current study we have demonstrated that proglumide (100 mg/kg three
times per day) blocks the trophic effect of a low dose of CCK octapeptide
(300 ng/kg) given three times a day for 2 days. The same dose of proglumide
when given alone for 6 days, however, resulted in a significant stimulation
of pancreatic growth. Proglumide had no effect on the trophic response to a
high dose of CCK-OP (5 micrograms/kg) administered for either 2 or 6 days.
These results indicate that given over a period of several days proglumide
behaves like a partial agonist of pancreatic growth.
