AJP - Gastrointestinal and Liver Physiology, Vol 250, Issue 1 127-G133, Copyright © 1986 by American Physiological Society
Calcitonin gene-related peptide-induced selective inhibition of gastric acid secretion in dogs
T. Pappas, H. T. Debas, J. H. Walsh, J. Rivier and Y. Tache
Calcitonin gene-related peptide (CGRP) is a 37-residue peptide recently
characterized in the brain and found in high concentrations in the gut,
particularly in the stomach and pancreas. The effects of intravenous
infusion of human and rat CGRP (260 pmol . kg-1 . h-1) on gastric secretion
and emptying and pancreatic exocrine secretion were studied in conscious
dogs. CGRP inhibited by 60-75% gastric acid secretion stimulated by a meal,
sham feeding, or step doses of bombesin but did not modify acid response to
step doses of histamine or bethanechol. The inhibitory effect of CGRP is
not due to blockage of postprandial or bombesin-stimulated gastrin release.
CGRP did not influence basal or meal-stimulated pancreatic exocrine
secretion or the rate of gastric emptying of a saline meal. These results
indicate that CGRP is a potent and selective inhibitor of gastrin-mediated
acid secretion in dogs and, under these conditions, did not alter other
gastrointestinal functions such as gastric emptying or pancreatic exocrine
secretion.
