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Am J Physiol Gastrointest Liver Physiol 251: G615-G618, 1986;
0193-1857/86 $5.00
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AJP - Gastrointestinal and Liver Physiology, Vol 251, Issue 5 615-G618, Copyright © 1986 by American Physiological Society

ARTICLES

Evidence for reflex adrenergic inhibition of acid secretion in the conscious rat

R. Dimaline, N. Carter and S. Barnes

In conscious gastric fistula rats, gastric distension with saline to a pressure of 7 cm caused a threefold reduction of basal gastric acid secretion. Distension with 6.25% peptone solution to the same pressure doubled basal acid secretion. The saline distension-induced inhibition was abolished by guanethidine and markedly reduced by propranolol; phentolamine was ineffective. The response to peptone was unaffected by guanethidine. The results suggest that in the rat, gastric distension at physiological pressures inhibits acid secretion by a beta-adrenergic reflex. The inhibition can be masked by concurrent chemical stimulation of the gastric mucosa by the digestion products of food.




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