AJP - Gastrointestinal and Liver Physiology, Vol 251, Issue 5 678-G681, Copyright © 1986 by American Physiological Society
Effects of cholecystokinin-octapeptide on gastric motility of anesthetized dogs
A. Kuwahara, K. Ozawa and N. Yanaihara
The present experiments examined the local effects of
cholecystokinin-octapeptide (CCK-8) and related peptides on gastric
motility of anesthetized dogs. Peptides were injected through the
gastroepiploic artery at doses of 1.0, 2.5, 5.0, 10.0, and 20.0 ng/ml.
CCK-8 and its analogues (Glt-CCK-8, pGlu-CCK-8, and Suc1-MePhe8-CCK-7)
increased gastric smooth muscle contraction in a dose-dependent manner.
ED50 of CCK-8 was 2.97 +/- 0.63 ng/ml. Administration of atropine (100-200
micrograms/kg) inhibited the effects of both CCK-8 and pentagastrin;
however, hexamethonium (5 mg/kg) failed to block the contractile response
induced by CCK-8 and pentagastrin. These results indicate that CCK-8 and
related peptides can act as local modulators in controlling the neural
regulation of gastric motility.
