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Am J Physiol Gastrointest Liver Physiol (October 1, 2009). doi:10.1152/ajpgi.00214.2009
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Research Article

Effects of intravenous fructose on gastric emptying and antropyloroduodenal motility in healthy subjects

Julie Eva Stevens,1 Selena Doran,2 Antonietta Russo,3 Deirdre O'Donovan,3 Christine Feinle-Bisset,1 Christopher K Rayner,3 Michael Horowitz,4 and Karen L. Jones4,*

1University of Adelaide Discipline of Medicine and NHMRC Centre of Clinical Research Excellence in Nutritional Physiology, Interventions and Outcomes 2University of Adelaide, Royal Adelaide Hospital 3Royal Adelaide Hospital 4University of Adelaide

Submitted 5 June 2009 ; revision received 28 September 2009 ; accepted in final form 28 September 2009

ABSTRACT

Gastric emptying (GE) of glucose is regulated closely, not only as a result of inhibitory feedback arising from the small intestine, but also because of the resulting hyperglycemia. Fructose is used widely in the diabetic diet and is known to empty from the stomach slightly faster than glucose, but substantially slower than water. The aims of this study were to determine whether intravenous (iv) fructose affects GE and antropyloroduodenal motility and how any effects compare to those induced by iv glucose. Six healthy males (age: 26.7±3.8yr) underwent concurrent measurements of GE of a solid meal (100g ground beef labeled with 20MBq 99mTc-sulfur colloid) and antropyloroduodenal motility on three separate days in randomized order during iv infusion of either fructose (0.5g/kg), glucose (0.5g/kg), or isotonic saline for 20min. GE (scintigraphy), antropyloroduodenal motility (manometry) and blood glucose (glucometer) were measured for 120min. There was a rise in blood glucose (P<0.001) after iv glucose (peak 16.4±0.6mmol/L), but not after fructose or saline. Intravenous glucose and fructose both slowed GE substantially (P<0.005 for both), without any significant difference between them. Between t=0-30min; the number of antral pressure waves was less after both glucose and fructose (P<0.002 for both) than saline, and there were more isolated pyloric pressure waves during iv glucose (P=0.003) compared with fructose and saline (P=NS for both) infusions. In conclusion, iv fructose slows gastric emptying and modulates gastric motility in healthy subjects, and the magnitude of slowing of gastric emptying is comparable to that induced by iv glucose.

gastric emptying; antropyloroduodenal motility; fructose; glucose


* University of Adelaide karen.jones{at}adelaide.edu.au






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